Osmosis Jones Easter Egg - Where Ron Howard Goes

Ron Howard, famed actor and director, does a brief voice cameo as Tom Colonic, a mayoral candidate who vows to "clean out the city of Frank". In one scene, while the current Mayor of Frank gives a speech to the city, the movie moves to Tom Colonic campaign headquarters where a group of his supporters listens to the address.

To the far left of the group, a caricatured version of Cliff Howard can be seen. As Cliff Howard is famed for appearing in almost all of Ron Howard's productions, it is a nice nod to that tradition.